Protection against aflatoxin B1 in rat--a new look at the link between toxicity, carcinogenicity, and metabolism.
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چکیده
منابع مشابه
Species comparison of in vitro metabolism of aflatoxin B1.
The metabolism of [14C]aflatoxin B1 by 9000 X g supernatant fraction of livers of duck, rat, mouse, monkey, and humans was compared by incubating the compound and liver fractions in the presence of cofactors and air for 30 min. The incubation medium was extracted with chloroform, and the soluble metabolites were separated on thinlayer plates and quantified; radioactivity remaining in the aqueou...
متن کاملProtection against aflatoxin B1-induced hepatic toxicity as short-term screen of cancer chemopreventive dithiolethiones.
Dithiolethiones are an important class of cancer chemopreventive agents. More than 50 new dithiolethione analogs were synthesized for structure-activity studies. Using selected dithiolethiones, studies were designed to measure protection against the hepatotoxicity of aflatoxin B1 (AFB1) and relate it to the protection against carcinogenicity. Young male F344 rats were pretreated with 0.1 or 0.3...
متن کاملTransgenic expression of aflatoxin aldehyde reductase (AKR7A1) modulates aflatoxin B1 metabolism but not hepatic carcinogenesis in the rat.
In both experimental animals and humans, aflatoxin B(1) (AFB(1)) is a potent hepatic toxin and carcinogen against which a variety of antioxidants and experimental or therapeutic drugs (e.g., oltipraz, related dithiolethiones, and various triterpenoids) protect from both acute toxicity and carcinogenesis. These agents induce several hepatic glutathione S-transferases (GST) as well as aldo-keto r...
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Most laboratory animals, with the exception of the mouse, are readily killed by the aflatoxins. Following the administration of aflatoxin B1 to the rat, the species most extensively studied, the main lesions are seen in the liver, while kidney and adrenals show damage. The other afiatoxins are less toxic to the the rat and duckling. Aflatoxin M1 is similar to B1 in its acute toxicity. The acute...
متن کاملApplication of Raman Technique in the Detection of Aflatoxins
Aflatoxin is one of the most important topics of research in food contamination . Aflatoxin, a member of the Mycotoxin family, is a secondary metabolite of molds such as Aspergillus Flavus and Aspergillus Parasiticus . These fungi also pollute the crops during production and storage . In the case of the products’ contamination with spores in the desired temperature and humidity conditions, the ...
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عنوان ژورنال:
- Toxicological sciences : an official journal of the Society of Toxicology
دوره 109 1 شماره
صفحات -
تاریخ انتشار 2009